The National Institutes of Health (NIH) has an upcoming June receipt date for a funding opportunity announcement to solicit phased cooperative research applications to conduct efficient large-scale pragmatic or implementation trials embedded within health care systems. A technical assistance webinar for potential applicants will be held on Tuesday, April 5, 2022, from 2 to 3 p.m. ET. We invite you to share information with your organization.  

RFA-AT-22-001: NIH Health Care Systems Research Collaboratory – Pragmatic and Implementation Trials of Embedded Interventions (UG3/UH3, Clinical Trials Optional)

The overall goal of this initiative is to support the “real world” assessment of health care strategies and clinical practices and procedures in health care systems that lead to improved care for populations in a variety of health care contexts, with a strong focus on populations with health disparities. Studies can propose to integrate multicomponent or multiple interventions that have demonstrated efficacy into health care systems or implement health care system changes to improve adherence to evidence-based guidelines. Trials should be conducted across three or more health care systems that provide care to patient populations and will become part of and work with the Collaboratory. The Collaboratory program has established a Collaboratory Coordinating Center (CCC) that provides national leadership and technical expertise in all aspects of research with health care systems. Awarded applicants will work with the CCC (rethinkingclinicaltrials.org) to facilitate further planning and refinement of the proposed study.

We will hold a technical assistance webinar on April 5, 2022 from 2 to 3 p.m. ET. During the webinar, we will explain Collaboratory funding opportunities and review requirements and details of this FOA. All participating Institutes and Centers will present their priorities for the FOA. Participants will have an opportunity to ask questions during the latter portion of the webinar. Registration is required, however, attendance at the webinar is not a requirement to apply. 

For more information, please refer to RFA-AT-22-001 and the Frequently Asked Questions document. We hope that you will register to join the webinar on April 5, if you have questions. In addition, we encourage you to contact scientific program staff at NCCIH or the other participating Institutes and Centers to share your research aims and determine whether you have a good match before developing an application.

Sincerely, 

Wendy J. Weber, N.D., Ph.D., M.P.H.
Branch Chief, Clinical Research in Complementary and Integrative Health Branch
Division of Extramural Research
National Center for Complementary and Integrative Health 

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List of Participating NIH Institutes, Centers, and Offices:

National Center for Complementary and Integrative Health (NCCIH)

National Heart, Lung, and Blood Institute (NHLBI)

National Institute on Aging (NIA)

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

National Institute of Nursing Research (NINR)

National Institute on Minority Health and Health Disparities (NIMHD)

Division of Program Coordination, Planning and Strategic Initiatives, Office of Disease Prevention (ODP)

Office of Behavioral and Social Sciences Research (OBSSR)